Gabapentin Chen J, Li L, Chen SR, Chen H, Xie JD, Sirrieh RE, MacLean DM, Zhang Y, Zhou MH, Jayaraman V, Pan HL. “The a2d-1-NMDA Receptor Complex is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions.” Cell Reports


 Dolino DM, Chatterjee S, MacLean DM, Flatebo C, Bishop LDC, Shaikh SA, Landes CF and Jayaraman V. “The structure-energy landscape of NMDA receptor gating.” Nat. Chem. Biology


Ian-1457945060-1502660680912.jpgCoombs ID*, MacLean DM*, Jayaraman V, Farrant M and Cull-Candy SG. “Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation.” Cell Reports


cropped-cropped-picture11-1.jpgMacLean DM, Jayaraman V. “Deactivation kinetics of Acid Sensing Ion Channel 1a are strongly pH-sensitive.” PNAS



Vitrac H, MacLean DM, Karlstaedt A, Taegtmeyer H, Jayaraman V, Bogdanov M, Dowhan W. “Dynamic lipid-dependent modulation of protein topology by post-translational phosphorylation.” JBC




Shaikh SA, Dolino DM, Lee G, Chatterjee S, MacLean DM, Flatebo C, Landes C, Jayaraman, V. “Stargazin modulation of AMPA receptors.” Cell Reports



MacLean DM, Jayaraman V. “Acid Sensing Ion Channels are tuned to follow high frequency stimuli.” J Physiol.



Heidi_2015Vitrac H, MacLean DM, Bogdanov M, Jayaraman V, Dowhan W. “Dynamic membrane protein topological switching upon changes in lipid environment.” PNAS


JGP_201511422_Fig5.jpgSirrieh RE, MacLean DM, Jayaraman V. “A conserved structural mechanism of NMDA receptor inhibition: A comparison of ifenprodil and zinc.” JGP


zbc0241516570008.jpgSirrieh RE, MacLean DM, Jayaraman V. “Subtype-dependent N-methyl-D-aspartate receptor amino-terminal domain conformations and modulation by spermine.” JBC


MacLean DM. “Constructing a rapid solution exchange system.” Ionotropic Glutamate Receptor Technologies.




MacLean DM, Ramaswamy S, Du M, Howe J, Jayaraman V. “Stargazin promotes closure of the AMPA receptor ligand-binding domain.” JGP


Garam2014Lee G*, MacLean DM*, Ulrich H, Zhao C, Aronowski J, Jayaraman V. “RNA based antagonism of NMDA receptors.” ACS Chem Neurosci.




zbc0031471010003.jpgRamaswamy S, MacLean DM, Gorfe AA, Jayaraman V. “Proton-mediated conformational changes in an acid-sensing ion channel.” JBC


Microsoft Word - TARPs modulate before the gating transitionresu

MacLean DM. “TARPs modulate AMPA receptor conformations before the gating transitions.” J Physiol.



Sirrieh RE, MacLean DM, Jayaraman V. “Amino-terminal domain tetramer organization and structural effects of zinc binding in the NMDA receptor.” JBC




SR_2012Ramaswamy S, Cooper D, Poddar N, MacLean DM, Rambhadran A, Taylor JN, Uhm H, Landes CF, Jayaraman V. “Role of conformational dynamics in alpha-amino-3-hydroxy-5-methylisoxazole-4-propinoic acid (AMPA) receptor partial agonism.” JBC



DM_DB_2012MacLean DM, Bowie D. “TARP modulation of AMPA receptor pharmacology: A problem of interpretation.” J Physiol.


DM_DB_2011 MacLean DM, Wong AY, Fay AM, Bowie D. “Cations but not anions regulate the responsiveness to Kainate receptor agonists.” J NRS



nihms-93325-f0007.jpgMacLean DM. “The delta2 glutamate-like receptor undergoes similar conformational changes as other ionotropic glutamate receptors.” J NRS (image from Hansen et al., 2009)




Wong AY, MacLean DM, Bowie D. “Na+/Cl- dipole couples agonist binding to Kainate receptor activation.” J NRS





Kuang D, Yao Y, MacLean DM, Wang M, Hampson DR, Chang BS. “Ancestral reconstruction of the ligand binding pocket of family C G-protein coupled receptors.” PNAS