Rook M, Musgaard M, MacLean DM. “Coupling structure with function in acid-sensing ion channels: Challenges in pursuit of proton sensors”. J Physiol.

Rook M, Williams A, Lueck JD, Musgaard M, MacLean DM. “Beta11-12 linker isomerization governs Acid-sensing ion channel desensitization and recovery”. eLife.

McCullock TW, MacLean DM, Kammermeier P. “Comparing the performance of mScarlet-I, mRuby3, and mCherry as FRET acceptors for mNeonGreen”. PLOS One.

Durham RJ, Paudyal N, Carillo E, Bhatia N, MacLean DM, Berka V, Dolino DM, Gorfe A, Jayaraman V. “Conformational spread and dynamics in allostery of NMDA receptors”. PNAS.

Carillo E, Shaikh S, Berka V, Durham RJ, Litwin DB, Lee G, MacLean DM, Nowak LM, Jayaraman V. “Mechanism of modulation of AMPA receptors by TARP-gamma 8”. Journal of General Physiology.



MacLean DM, Durham RJ, Jayaraman V. “Mapping the conformational landscape of glutamate receptors using single molecule FRET.” Trends in Neurosci.


Gabapentin Chen J, Li L, Chen SR, Chen H, Xie JD, Sirrieh RE, MacLean DM, Zhang Y, Zhou MH, Jayaraman V, Pan HL. “The a2d-1-NMDA Receptor Complex is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions.” Cell Reports


Dolino DM, Chatterjee S, MacLean DM, Flatebo C, Bishop LDC, Shaikh SA, Landes CF and Jayaraman V. “The structure-energy landscape of NMDA receptor gating.” Nat. Chem. Biology

Ian-1457945060-1502660680912.jpgCoombs ID*, MacLean DM*, Jayaraman V, Farrant M and Cull-Candy SG. “Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation.” Cell Reports

cropped-cropped-picture11-1.jpgMacLean DM, Jayaraman V. “Deactivation kinetics of Acid Sensing Ion Channel 1a are strongly pH-sensitive.” PNAS


Vitrac H, MacLean DM, Karlstaedt A, Taegtmeyer H, Jayaraman V, Bogdanov M, Dowhan W. “Dynamic lipid-dependent modulation of protein topology by post-translational phosphorylation.” JBC



Shaikh SA, Dolino DM, Lee G, Chatterjee S, MacLean DM, Flatebo C, Landes C, Jayaraman, V. “Stargazin modulation of AMPA receptors.” Cell Reports


MacLean DM, Jayaraman V. “Acid Sensing Ion Channels are tuned to follow high frequency stimuli.” J Physiol.


Heidi_2015Vitrac H, MacLean DM, Bogdanov M, Jayaraman V, Dowhan W. “Dynamic membrane protein topological switching upon changes in lipid environment.” PNAS

JGP_201511422_Fig5.jpgSirrieh RE, MacLean DM, Jayaraman V. “A conserved structural mechanism of NMDA receptor inhibition: A comparison of ifenprodil and zinc.” JGP

zbc0241516570008.jpgSirrieh RE, MacLean DM, Jayaraman V. “Subtype-dependent N-methyl-D-aspartate receptor amino-terminal domain conformations and modulation by spermine.” JBC


MacLean DM. “Constructing a rapid solution exchange system.” Ionotropic Glutamate Receptor Technologies.



MacLean DM, Ramaswamy S, Du M, Howe J, Jayaraman V. “Stargazin promotes closure of the AMPA receptor ligand-binding domain.” JGP

Garam2014Lee G*, MacLean DM*, Ulrich H, Zhao C, Aronowski J, Jayaraman V. “RNA based antagonism of NMDA receptors.” ACS Chem Neurosci.


zbc0031471010003.jpgRamaswamy S, MacLean DM, Gorfe AA, Jayaraman V. “Proton-mediated conformational changes in an acid-sensing ion channel.” JBC

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MacLean DM. “TARPs modulate AMPA receptor conformations before the gating transitions.” J Physiol.


Sirrieh RE, MacLean DM, Jayaraman V. “Amino-terminal domain tetramer organization and structural effects of zinc binding in the NMDA receptor.” JBC


SR_2012Ramaswamy S, Cooper D, Poddar N, MacLean DM, Rambhadran A, Taylor JN, Uhm H, Landes CF, Jayaraman V. “Role of conformational dynamics in alpha-amino-3-hydroxy-5-methylisoxazole-4-propinoic acid (AMPA) receptor partial agonism.” JBC


DM_DB_2012MacLean DM, Bowie D. “TARP modulation of AMPA receptor pharmacology: A problem of interpretation.” J Physiol.

DM_DB_2011 MacLean DM, Wong AY, Fay AM, Bowie D. “Cations but not anions regulate the responsiveness to Kainate receptor agonists.” J NRS


nihms-93325-f0007.jpgMacLean DM. “The delta2 glutamate-like receptor undergoes similar conformational changes as other ionotropic glutamate receptors.” J NRS (image from Hansen et al., 2009)



Wong AY, MacLean DM, Bowie D. “Na+/Cl- dipole couples agonist binding to Kainate receptor activation.” J NRS



Kuang D, Yao Y, MacLean DM, Wang M, Hampson DR, Chang BS. “Ancestral reconstruction of the ligand binding pocket of family C G-protein coupled receptors.” PNAS