Dave was born and raised in Toronto, Canada. He graduated from the University of Toronto in 2005 with a degree in Neuroscience & a minor in Psychology. While there he worked with both Dr. David Hampson and Dr. John F. MacDonald, in whose labs he developed a strong interest in structure-function of neurotransmitter receptors and channels as well as some experience with basic lab technique and electrophysiology.  He did his graduate work with Dr. Derek Bowie in McGill’s Pharmacology Department, learning patch clamp, fast perfusion methods and kinetic modelling. During his postdoctoral training with Dr. Vasanthi Jayaraman at UTHealth in Houston Texas he picked up expertise in fluorescence/luminescence resonance energy transfer, unnatural amino acid incorporation and membrane protein purification for structural biology. When not in the lab, Dave is an enthusiastic (though unskilled) rock climber, brunch connoisseur and Thor labs T-shirt collector.

Lab Technician

Lyndee was born and raised in a little town southeast of Syracuse, NY. She graduated from RIT in 2005 with a degree in Biotechnology, with a minor in Psychology. Upon graduating she started working here at the University of Rochester. She recently joined the MacLean lab in June of 2017. When Lyndee is not in the lab she loves to spend time with her husband and son, hiking, building legos, watching Hockey and Football (Go Pats)!​


Kyle was raised on Grand Island, NY.  He obtained his B.S. in Biochemistry with a minor in Mathematics from SUNY Fredonia in 2009 and M.S. in Chemistry from SUNY Fredonia in 2011.  In early 2019, he completed his PhD in biophysics at the University of Rochester.  His PhD research investigated the occurrence/structure of GU pairs near internal loops within RNA.  The research was advised by Dr. Doug Turner of the UR Chemistry department.  Shortly after completing his PhD, he accepted a postdoc position in the MacLean lab.  There, he hopes to learn more about iGluR and ASIC structure/function.  Outside of the lab, Kyle enjoys playing soccer, snowboarding, and reading.  Additionally, he and his wife have a 2-year-old Olde English Bulldogge named Louie.

Graduate Students

Rook Matthew 72webMatthew was born and raised in Rochester. He graduated from the University at Buffalo in 2015 with a Bachelors of Science in Pharmacology and Toxicology. Matthew started his graduate studies in July 2017 as a Masters student in the Pharmacology and Physiology program. In the Fall, Matthew rotated in the MacLean Lab where he learned his favorite experiment, patch clamping! He joined the lab in March 2018 and will successfully transfer to the Cellular and Molecular Pharmacology and Physiology PhD program beginning in July 2018. He looks forward to progressing our understanding of acid-sensing ion channels! Outside of the lab, Matthew enjoys intramural volleyball, playing video games and watching football (avid Raiders and Bills fan!).

Lab Mascot Alumni

Archie was a Jade Bonsai plant grow in the local Rochester area. While his namesake, Archibald Vivian Hill, developed the first mathematical description of receptor function, Archie’s ambitions were more modest. He enjoyed sunlight, a nice re-potting and water (but not too much water). Apparently too much water leads to root rot and can kill bonsais….

Open Positions

As a new lab we have a variety of positions available to study the structure, function and physiology of ASICs and iGluRs.


Postdoc position available!

Possible Projects: Structure-function relationships in iGluRs and auxiliary proteins (see here, here and hereor  the role of ASICs in synaptic plasticity

Requirements: Enthusiastic, internally motivated and with expertise in one of either recombinant electrophysiology, fluorescence spectroscopy or brain slice electrophysiology.

Interested?: Send your CV, short cover letter and names of 3 references to David_MacLean@URMC.Rochester.edu.

Graduate Students

Grad student positions available!

Possible Projects: Evaluating the physiological role of ASIC kinetic plasticity or Structure-function relationships in iGluRs and auxiliary proteins.

Requirements: An interest and aptitude in either neuroscience, membrane protein function or quantitative methods. Lab experience is preferred but not necessary. We can take rotation students from Pharmacology and Physiology, Neuroscience or Biophysics, Structural and Computational Biology programs.

Interested?: Send your CV and short cover letter to David_MacLean@URMC.Rochester.edu.

Undergraduate Students

Undergraduates looking to either gain research experience or (preferably) broaden existing experience are invited to send your CV and short cover letter to David_MacLean@URMC.Rochester.edu. Undergraduates from physics, photonics, engineering and computer science are especially encouraged to apply. Please also check out the U of R Undergraduate Placement Program.